Table 4.

Selected genetically engineered pigs for xenotransplantation.

Genetic Modification	Function	Reference
GGTA1 knock-out	deletion of Gal xenoantigen	[59,60]
CMAH knock-out	deletion of Neu5Gc xenoantigen	[106]
β4GALNT2 knock-out	deletion of SDa xenoantigen	[64]
expression of human CD55 gene	complement regulation	[107]
expression of human CD46 gene	complement regulation	[108]
expression of human CD59 gene	complement regulation	[65]
expression of human TBM gene	coagulation regulation	[109]
expression of human EPCR gene	coagulation regulation	[74]
expression of human TFPI gene	coagulation regulation	[77]
expression of human CD39 gene	coagulation regulation	[79]
expression of human HO-1 gene	anti-inflammatory/antiapoptotic	[80]
expression of human A20 gene	anti-inflammatory/antiapoptotic	[81]
expression of HLA-E	regulation of NK-cells-mediated responses	[83,84]
ULBP1 knock-out	regulation of NK-cells-mediated responses	[87]
expression of human CD47 gene	regulation of macrophage-mediated responses	[90]
expression of human CTLA4-Ig	regulation of T cells-mediated responses	[92]
SLA class I knock-out	regulation of T cells-mediated responses	[94]
PERV inactivation	xenozoonosis	[96]