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. 2020 Jun 19;11(6):670. doi: 10.3390/genes11060670

Table 4.

Selected genetically engineered pigs for xenotransplantation.

Genetic Modification Function Reference
GGTA1 knock-out deletion of Gal xenoantigen [59,60]
CMAH knock-out deletion of Neu5Gc xenoantigen [106]
β4GALNT2 knock-out deletion of SDa xenoantigen [64]
expression of human CD55 gene complement regulation [107]
expression of human CD46 gene complement regulation [108]
expression of human CD59 gene complement regulation [65]
expression of human TBM gene coagulation regulation [109]
expression of human EPCR gene coagulation regulation [74]
expression of human TFPI gene coagulation regulation [77]
expression of human CD39 gene coagulation regulation [79]
expression of human HO-1 gene anti-inflammatory/antiapoptotic [80]
expression of human A20 gene anti-inflammatory/antiapoptotic [81]
expression of HLA-E regulation of NK-cells-mediated responses [83,84]
ULBP1 knock-out regulation of NK-cells-mediated responses [87]
expression of human CD47 gene regulation of macrophage-mediated responses [90]
expression of human CTLA4-Ig regulation of T cells-mediated responses [92]
SLA class I knock-out regulation of T cells-mediated responses [94]
PERV inactivation xenozoonosis [96]