Figure 5.

Rab27a^ash/ash mice show normal responses in basal mechanical and nociceptive pain models. (A–B) Reaction to basal mechanical stimuli, as assessed by the Dynamic plantar test (A, n = 20–22) or the tape response assay (B, n = 19) are not affected in Rab27a^ash/ash mice. (C) Rab27a^ash/ash mice show slightly reduced pain behavior in the hot plate test at 52 °C, while their responses at 50 °C and 54 °C were comparable to those of WT mice (C, n = 19). (D–E) Formalin-induced nociceptive pain behavior is normal in Rab27a^ash/ash mice (n = 5–6); * p < 0.05.