Figure 6.

Rab27a^ash/ash mice show reduced pain behavior in inflammatory pain models. (A) Mechanical hypersensitivity after zymosan injection into a hind paw is significantly reduced in Rab27a^ash/ash mice compared to WT littermates (n = 5). (B) Western blot analyses revealed that Rab27a protein expression in the spinal is significantly upregulated 4 and 8 h after zymosan injection into a hind paw of WT mice (n = 6). (C) Rab27a^ash/ash mice show reduced pain behavior in the Complete Freund′s Adjuvant (CFA)-model of inflammatory pain as assessed by the dynamic weight bearing (n = 6); * p < 0.05.