Figure 1.
The shape of epithelial tissue and fabricated convex geometric structure. (A) A schematic of flat and curved epithelium on the designed protruded geometry; triangle, square and circle shape, respectively. The height and diameter of triangle, square, and circle ring structure is fixed as 60 μm. For the cell culture, fibronectin was fully covered on both protruded structure and flat surface. (B) The schematics showing cell orientation (∆θ) on the structure. ∆θ were measured from main axis of cells from the center of each structure (Pa); triangle, square, circle geometry. When the cells are oriented from reference axis from Pa in longitudinal (L) or perpendicular (P) direction, ∆θ equals 0° or 90°, respectively. The scanning electron microscope (SEM) images of the fabricated structure are shown in the bottom panel.