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. 2020 Jun 4;9(6):1404. doi: 10.3390/cells9061404

Figure 1.

Figure 1

Schematic representation of the Hepatitis B Virus (HBV) envelope glycoproteins. S, M and L proteins contain four transmembrane domains (TM I-IV) and share a common S domain (blue). HBV-M is extended with the preS2 domain (orange) at the N-terminus, while HBV-L has an additional pre-S1 domain (green). HBV-L is characterized by a dual topology of the pre-S region, facing either the ER lumen (solid line) or the cytosol (dashed line). The two functional N-glycosylation sites are indicated: N4 in the preS2 region, occupied only in HBV-M; and N146 in the major hydrophilic region (MHR) of the S domain, occupied in half (in square brackets) of all three proteins [6]. The complex structure of the N-glycans is represented [10,11]. The O-glycosylation site identified in the preS2 domain of HBV-M is also shown (*) [10].