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. 2020 Jun 3;9(6):1393. doi: 10.3390/cells9061393

Figure 2.

Figure 2

Effect of PDE5A inhibition on burn-induced cardiac dysfunction. Sprague–Dawley rats were randomized to a 60% TBSA scald burn or sham procedure with standard resuscitation with/without sildenafil (SIL). Heart function was measured using ECHO (Vevo® 2100 System) at 24 h post burn (24 hpb ± SIL). Shown are (A) cardiac output (CO), (B) ejection fraction (EF), (C) stroke volume (SV), (D) left ventricular posterior wall at diastole (LVPW), (E), fractional shortening (FS) and (F) left ventricular systolic volume (LV Vol.). Data are presented as mean value ± SD, shown as **, && p < 0.01, ***, &&& p < 0.001 (n = ≥ 6 per group).