Table 4.
Gene ontology enrichment for differentially expressed genes in macrophages 17 h after infection with FIPV.
| Gene Ontology for Genes Differentially Downregulated at 17 h | |||
| GO Molecular Function Complete | Fold Enrichment | Raw p-Value | FDR |
| extracellular matrix binding (GO:0050840) | 90.54 | 6.35 × 10−6 | 2.37 × 10−2 |
| collagen binding (GO:0005518) | 61.83 | 1.85 × 10−5 | 3.45 × 10−2 |
| GO Biological Process Complete | Fold Enrichment | Raw p-Value | FDR |
| regulation of endothelial cell proliferation (GO:0001936) | 56.33 | 3.29 × 10−8 | 4.49 × 10−4 |
| positive regulation of angiogenesis (GO:0045766) | 34.14 | 6.07 × 10−6 | 2.76 × 10−2 |
| positive regulation of vasculature development (GO:1904018) | 31.01 | 8.77 × 10−6 | 2.99 × 10−2 |
| regulation of epithelial cell proliferation (GO:0050678) | 19.84 | 4.81 × 10−6 | 3.28 × 10−2 |
| regulation of peptidase activity (GO:0052547) | 16.31 | 1.22 × 10−5 | 3.33 × 10−2 |
| Gene Ontology for Genes Differentially Upregulated at 17 h | |||
| GO Molecular Function Complete | Fold Enrichment | Raw p-Value | FDR |
| condensed nuclear chromosome outer kinetochore (GO:0000942) | >100 | 1.99 × 10−5 | 3.32 × 10−2 |
| GO Molecular Function Complete | Fold Enrichment | Raw p-Value | FDR |
| regulation of spindle organization (GO:0090224) | >100 | 4.63 × 10−6 | 1.26 × 10−2 |
| establishment of spindle orientation (GO:0051294) | >100 | 4.63 × 10−6 | 1.05 × 10−2 |
| establishment of spindle localization (GO:0051293) | 83.29 | 8.53 × 10−6 | 1.16 × 10−2 |
| spindle localization (GO:0051653) | 69.41 | 1.41 × 10−5 | 1.75 × 10−2 |
| mitotic spindle organization (GO:0007052) | 48.43 | 3.88 × 10−5 | 3.79 × 10−2 |
| mitotic sister chromatid segregation (GO:0000070) | 45.52 | 2.18 × 10−6 | 1.49 × 10−2 |
| microtubule cytoskeleton organization involved in mitosis (GO:1902850) | 45.52 | 2.18 × 10−6 | 9.94 × 10−3 |
| mitotic nuclear division (GO:0140014) | 41.32 | 1.61 × 10−7 | 2.20 × 10−3 |
| sister chromatid segregation (GO:0000819) | 35.6 | 5.55 × 10−6 | 9.47 × 10−3 |
| spindle organization (GO:0007051) | 35.14 | 5.82 × 10−6 | 8.83 × 10−3 |
| nuclear chromosome segregation (GO:0098813) | 22.04 | 3.44 × 10−5 | 3.91 × 10−2 |
| nuclear division (GO:0000280) | 21.69 | 3.46 × 10−6 | 1.18 × 10−2 |
| organelle fission (GO:0048285) | 19.83 | 5.29 × 10−6 | 1.03 × 10−2 |
| mitotic cell cycle process (GO:1903047) | 13.3 | 3.49 × 10−5 | 3.66 × 10−2 |
| microtubule cytoskeleton organization (GO:0000226) | 12.48 | 4.69 × 10−5 | 4.27 × 10−2 |