Table 2.
HLA-DPB1 Allele Frequencies Among Different Age of Multiple Sclerosis (MS) Onset Groups of Patients.
| Early MS | Adult MS | HCs | Early vs. Adult MS | Early MS vs. HCs | Adult MS vs. HCs | |
|---|---|---|---|---|---|---|
| (N = 28) | (N = 72) | (N = 246) | Sig 1 | Sig 2 | Sig 2 | |
| HLA-DPB1*01 | 3.6 | 4.2 | 4.5 | 0.85 (0.09–8.55) 1.000 |
0.79 (0.1–6.37) 0.500 |
0.92 (0.25–3.42) 0.500 |
| HLA-DPB1*02 | 39.3 | 22.2 | 36.6 | 2.27 (0.89–5.80) 0.131 |
1.12 (0.5–2.5) 0.461 |
0.5 (0.23–0.91) 0.008 ** |
| HLA-DPB1*03 | 17.9 | 23.6 | 13.4 | 0.7 (0.23–2.13) 0.602 |
1.4 (0.50–3.95) 0.339 |
2.0 (1.04–3.84) 0.009 ** |
| HLA-DPB1*04 | 64.3 | 79.2 | 92.7 | 0.47 (0.18–1.24) 0.132 |
0.14 (0.06–0.35) <0.001 ** |
0.3 (0.14–0.63) <0.001 ** |
| HLA-DPB1*05 | 3.6 | 2.8 | 2.4 | 1.3 (0.11–14.89) 1.000 |
1.48 (0.17–12.77) 0.500 |
1.14 (0.23–5.79) 0.500 |
| HLA-DPB1*06 | 0 | 1.4 | 0.8 | - 1.000 |
- 0.500 |
1.72 (0.15–19.23) 0.500 |
| HLA-DPB1*09 | 0 | 1.4 | 2.8 | - 1.000 |
- 0.372 |
0.48 (0.06-3.97) 0.356 |
| HLA-DPB1*10 | 10.7 | 9.7 | 4.9 | 1.11 (0.27–4.65) 1.000 |
2.34 (0.62–8.85) 0.162 |
2.1 (0.8–5.55) 0.052 |
| HLA-DPB1*11 | 0 | 1.4 | - | - 1.000 |
- | - |
| HLA-DPB1*13 | 3.6 | 2.8 | 6.1 | 1.3 (0.11–14.89) 1.000 |
0.57 (0.07–4.49) 0.435 |
0.44 (0.1–1.97) 0.176 |
| HLA-DPB1*14 | 7.1 | 6.9 | 3.7 | 1 (0.18–5.48) 1.000 |
2.03 (0.42–9.88) 0.321 |
1.97 (0.64–6.06) 0.126 |
| HLA-DPB1*15 | 0 | 4.2 | 2.0 | - 0.557 |
- 0.468 |
2.1 (0.49–8.99) 0.186 |
| HLA-DPB1*19 | 0 | 1.4 | 0.4 | - 1.000 |
- 0.500 |
3.45 (0.21–55.87) 0.346 |
| HLA-DPB1*22 | 3.6 | 0 | - | - 0.280 |
- | - |
| HLA-DPB1*23 | 3.6 | 0 | 2.4 | - 0.280 |
1.48 (0.17–12.77) 0.500 |
- 0.172 |
| HLA-DPB1*32 | 3.6 | 0 | 0.8 | - 0.280 |
4.52 (0.4–51.49) 0.279 |
- 0.460 |
| HLA-DPB1*33 | 3.6 | 2.8 | 0.4 | 1.3 (0.11–14.89) 1.000 |
9.07 (0.55–149.24) 0.123 |
7.0 (0.63–78.34) 0.130 |
| HLA-DPB1*34 | 0 | 1.4 | - | - 1.000 |
- | - |
| HLA-DPB1*35 | 0 | 4.2 | 0.8 | - 0.557 |
- 0.500 |
10.65 (1.09–104.03) 0.005 ** |
| HLA-DPB1*38 | 3.6 | 0 | - | - 0.280 |
- | - |
| HLA-DPB1*46 | 3.6 | 0 | - | - 0.280 |
- | - |
| HLA-DPB1*50 | 0 | 1.4 | 0.4 | - 1.000 |
- 0.500 |
3.45 (0.21–55.87) 0.346 |
| HLA-DPB1*56 | 0 | 1.4 | - | - 1.000 |
- | - |
Numbers represent frequencies (%). 1 Fishers’s exact test (23 comparisons) 2 Binomial tests (17 comparisons). ** p ≤ 0.015 (17 comparisons) or p ≤ 0.013 (23 comparisons), according to the Benjamini–Yekutieli method for 17 comparisons, HCs: Healthy Control