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. 2020 Jun 12;8(2):21. doi: 10.3390/diseases8020021

Figure 1.

Figure 1

Panel A: Patients with primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC) were subgrouped by presence of cirrhosis. The number of CTLA-4 copies was measured using mRNA Real-Time PCR and normalized by β-Actin as internal control. The X marks the mean value, the line inside the boxplot the median. Patients with cirrhosis have a mean number of 4359 copies, patients without cirrhosis have a mean number of 6836 copies (p = 0.04). Panel B: Patients with PBC were sorted by the determined number of CTLA-4 copies. Three equally large groups with either low, medium or high expression were formed. Patients with high and low expression were compared in the course of their disease by subtracting the lab values at initial diagnosis with the most current values for each patient. Patients with high CTLA-4 tend to have a recovery of elevated GGT-values more often [low: −69.8 U/l vs. high: −176.1 U/l p = 0.04]. The X marks the mean value, the line inside the boxplot the median. Patients with PSC showed the same trend without reaching statistical significance (low: −45.3 U/l vs. high: −105.4 U/l p = 0.08).