Table 3.
PD-L1 expression in non-neoplastic mucosa (“distant from” and “adjacent to” tumour) and adenocarcinomas of CVID patients in comparison with non-CVID patients.
| Feature | CVID Patients | Non-CVID Patients | p Value |
|---|---|---|---|
| 1. Non-neoplastic mucosa distant from gastric cancer (intraepithelial) | |||
| n = 7/9 | n = 21/21 | ||
| Positive intraepithelial lymphocytes Negative |
3/7 (42.9%) 4/7 (57.1%) |
0/21 (0.0%) 21/21 (100.0%) |
0.011 * |
| 2. Non-neoplastic mucosa distant from gastric cancer (lamina propria) | |||
| n = 7/9 | n = 21/21 | ||
| <10% positive immune cells ≥10% positive immune cells |
4/7 (57.1%) 3/7 (42.9%) |
21/21 (100.0%) 0/21 (0.0%) |
0.011 * |
| 3. Non-neoplastic mucosa adjacent to gastric cancer (intraepithelial) | |||
| n = 7/9 | n = 21/21 | ||
| Positive intraepithelial lymphocytes Negative |
3/7 (42.9%) 4/7 (57.1%) |
1/21 (4.8%) 20/21 (95.2%) |
0.038 * |
| 4. Non-neoplastic mucosa adjacent to gastric cancer (lamina propria) | |||
| n = 7/9 | n = 21/21 | ||
| <10% positive immune cells ≥10% positive immune cells |
5/7 (71.4%) 2/7 (28.6 %) |
21/21 (100.0%) 0/21 (0.0%) |
0.056 |
| 5. Gastric cancer (combined positive score) [27] | |||
| n = 9/9 | n = 21/21 | ||
| <1% 1–50% >50% |
2 (22.2%) 7 (77.8%) 0 (0.0%) |
10 (47.6%) 8 (38.1%) 3 (14.3%) |
0.117 |
Statistically significant results are highlighted by an asterisk (*).