Figure 3.

Roles of the mTORC2 complex in transcriptional and epigenetic regulation. Dashed arrows indicate regulation that is either indirect, or not yet known to be direct. Solid lines indicate direct regulation. P denotes phosphorylation. Yellow circles indicate proteins that physically interact with mTORC2. Blue circles indicate proteins that are regulated by mTORC2 or AKT outside of the nucleus. The link between mTORC2 and BRCA1 (grey letters) is more recent and yet to be tested more rigorously.