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. 2020 Jun 10;11(6):641. doi: 10.3390/genes11060641

Figure 4.

Figure 4

Role of the SpTORC2 complex in transcriptional and epigenetic regulation. Dashed arrows indicate regulation that is either indirect, or not yet known to be direct. Solid lines indicate direct regulation. P denotes phosphorylation. The P circled with a dashed line indicates uncertainty about in vivo phosphorylation. Yellow circles indicate proteins that physically interact with Gad8. Notably, Paf1, Leo1, Taf12, and Pab1 are found primarily in the nucleus.