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. 2020 Jun 17;9(6):1479. doi: 10.3390/cells9061479

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Regeneration of mouse skeletal muscles which received control hADSCs or hADSCs pretreated with IL-4 and SDF-1. (A) Weight of non-injured (NIM), injured control (NaCl), control hADSC (ADSCsC), and IL-4 and SDF-1 treated hADSC (ADSCsT) transplanted skeletal muscles related to the weight of the mouse, day 7, 14 and 30 of regeneration. (B) Expression of human mRNAs encoding CD90, LMNA, CXCR7, CD9, LAMA3, and BLIM1 in control and regenerating mouse muscles. Expression was normalized to mRNA encoding HPRT. (C) Localization of hADSCs within the skeletal muscle at day 7, 14, and 30 of regeneration using visualization of human nuclei (red) and all nuclei (blue), bar = 20 µm. (D) Number of hADSCs per field of view in injured control and ADSC transplanted skeletal muscles at day 7, 14, and 30 of regeneration. CTX7 - day 7; CTX14 - day 14; CTX30 - day 30 of regeneration, For each experimental group n ≥ 3. Data are presented as mean ± SD. Data have been analyzed using Kruskal-Wallis test.