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. 2020 Jun 4;11(6):616. doi: 10.3390/genes11060616

Figure 1.

Figure 1

Mutational status of EHMT2/G9a and its relationship with mRNA expression in human colorectal tumors. (A) Domain architecture of the EHMT2 gene and mutations reported in Colorectal Adenocarcinoma TCGA PanCancer Atlas dataset, including 524 cases. (B) Distribution of EHMT2 genomic aberrations and mutations vs. mRNA expression (z-scores vs. diploid samples, RNA Seq V2 RSEM) in human colorectal tumors (n = 524 cases). (C) EHMT2 and APC mutation frequency from eight datasets. * A total of 3407 independent patients were queried due to patients overlap between some specific datasets. (D) Distribution of EHMT and/or APC-mutated cases across a dot chart of both genes’ expression levels (RSEM batch normalized from Illumina HiSeq_RNASeqV2) (n = 524 cases).