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Pedigree, temporal bone CT, variant analysis, and audiogram of family B. (a) Affected subjects are denoted in black. Arrow shows the proband. (b) Temporal bone CT of the III:1 shows no structural change. (c) Chromatogram shows POU4F3 heterozygous c.325C>T detected in patients. (d) Audiograms of the affected subjects. Hearing loss appears to involve high frequency (red: right ear; blue: left ear).
