Table 1.
Demographic, molecular and medication information for participants included in the study. QD: once a day; BID: twice a day; TID: three times a day; QHS: every night at bedtime; QAM: every morning.
| Participants | Age | Gender | Mutation Category | CGG Repeat | % Meth. | Activation Ratio | FMR1 mRNA ± StErr | Metformin Dose | Duration of Treatment (Months) | Other Ongoing Treatments |
|---|---|---|---|---|---|---|---|---|---|---|
| Case 1 | 25 | M | Meth mosaic | >200 (250–480) | 78% | 0.21 ± 0.004 | 1000 mg BID | 28 | Abilify 10 mg QD Effexor 75 mg QD |
|
| Case 2 | 10 | M | Full mutation | >200 | 0 | 500 mg BID | 15 | Sertraline 50 mg QD Abilify 5 mg QHS Guanfancine 2 mg BID Minocycline 100 mg QD CBD and THC 2:1 |
||
| Case 3 | 7 | M | Full mutation | >200 | 0.13 ± 0.0001 | 500 mg BID | 6 | Clonidine 0.1 mg TID& 0.2 at QHS Adderall 2.5 mg TID Trileptal 420 mg BID |
||
| Case 4 | 1 | M | Full mutation | >200 | 0.001 ± 0.00 | 150 mg BID | 9 | Melatonin 2 mg Sertraline 4 mg QD |
||
| Case 5 | 2 | M | Full mutation | >200 | 0 | 50 mg BID | 4 | Melatonin 2 mg Sertraline 2.5 mg QAM |
||
| Case 6 | 23 | M | Full mutation | >200 | 0 | 500 mg BID | 16 | Vitamin D Fish Oil Pravastatin 10 mg QD |
||
| Case 7 | 3 | F | Size mosaic | 28, >200 (54) | 93% | 0.38 | 0.95 ± 0.13 | 100 mg BID | 7 | Sertraline 0.2 mL (Zoloft 20 mg/mL) |
| Case 8 | 3 | F | Full mutation | 30, >200 | 0.5 | 0.83 ± 0.03 | 100 mg BID | 1 | Melatonin Multivitamin | |
| Case 9 | 5 | F | Full mutation | 30, 240 | 0.52 | 1.01 ± 0.03 | 200 mg BID | 9 | Sertraline 20 mg QD Melatonin 5 mg QHS |
|
| Case 10 | 19 | M | Full mutation | >200 | 0.05 ±0.00 | 500 mg QD | 26 | |||
| Case 11 | 67 | M | Full mutation | >200 | 0.07 ± 0.01 | 1500 mg TID | 28 | Sertraline 50 mg | ||
| Case 12 | 8 | F | Meth. mosaic | 31, >200 (360) | 92% | 0.42 | 0.26 ± 0.01 | 500 mg BID | 1 | |
| Case 13 | 2 | M | Meth. mosaic | >200 (180–300) | 82% | NA | 500 mg BID | 4 | Sertraline 13 mL QD Multivitamins. | |
| Case 14 | 10 | M | Full mutation | >200 | 0 | 500 mg BID | 7 | Sertraline 25 mg Multivitamin Aripiprazole (Abilify) 2 mg Clonidine 01 mg qD + H15:H21 |
||
| Case 15 | 8 | M | Full mutation | >200 | 0 | 500 mg BID | 1 | |||
| Case 16 | 2 | F | Full mutation | 29, >200 | 0.43 | 0.4 ± 0.01 | 50 mg BID | 30 | Melatonin 1 mg/Ml Sertraline HCL 2.5 mg QD Metformin 50 mg BID |
|
| Case 17 | 7 | M | Full mutation | >200 | 0 | 500 mg BID | 11 | Guanfacine HCK Aripiprazole (Abilify) 5 mg QD Clonidine 0.1 mg QD |