Table 2.
Patient molecular barcode representing change in MMP9, HK1, and Ras plasma expression levels; clinical measures including CGI-I post treatment; and change in BMI post metformin treatment relative to each patient’s own baseline. Blood samples for each participant before and after metformin treatment were processed within 2 h of collection time for plasma isolation. MMP9 expression was measured by Luminex xMAP technology. Ras and HK1 expression levels were measured by Western blot. Cut-off ±5% was used; increased expression was >5%, decreased expression was <5%.
| Participants | Age | Gender | MMP9/MMP2 Changes | HK1 Changes | Ras Changes | CGI-I Score | BMI Move Towards Normal? |
|---|---|---|---|---|---|---|---|
| Case 1 | 25 | M | 0.46 | 1.08 | 3.92 | 2 | yes |
| Case 2 | 10 | M | 1.09 | 0.65 | - | 2 | NA |
| Case 3 | 7 | M | 0.81 | 0.73 | 1.1 | 1 | stay normal |
| Case 4 | 1 | M | 0.65 | 1.08 | 1.37 | 3 | stay normal |
| Case 5 | 2 | M | 1.64 | 0.65 | - | 2 | yes |
| Case 6 | 23 | M | 0.25 | 6.75 | 1.22 | 1 | yes |
| Case 7 | 3 | F | 1.75 | 0.99 | 1.1 | 2 | yes |
| Case 8 | 3 | F | 0.96 | 1.01 | 2.07 | 4 | NA |
| Case 9 | 5 | F | 0.82 | 1.14 | 2.6 | 4 | NA |
| Case 10 | 19 | M | 1.41 | 1.34 | 1.07 | 3 | yes |
| Case 11 | 67 | M | 5.36 | 0.94 | 0.53 | 2 | no |
| Case 12 | 8 | F | 1.48 | 0.9 | 2.45 | 3 | NA |
| Case 13 | 2 | M | 1.33 | 1.18 | 2.07 | 2 | yes |
| Case 14 | 10 | M | 1.87 | 0.88 | 1.1 | 3 | yes |
| Case 15 | 8 | M | 0.66 | 0.48 | 1.18 | 2 | NA |
| Case 16 | 2 | F | 1.54 | 1.46 | 1.01 | 1 | yes |
| Case 17 | 7 | M | 2.62 | 0.86 | 0.94 | NA | NA |