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. 2020 Apr 25;8(2):198. doi: 10.3390/vaccines8020198

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Histopathology analysis of the different organs from IV-infected mice. (A) Hematoxylin and eosin staining of lungs, spleens and livers from PBS, γ-irradiated-M. brumae, M. brumae and BCG- IV infected mice. Only BCG-infected mice showed lesions consisting of granulomas with inflammatory component (*, black asterisks). The lesions were massive, showing in some organs a coalescent pattern (note lung and spleen sections). (B) A score (0 to 4) in accordance with the degree of the histological findings. Only BCG-infected mice exhibited systemic injuries of maximum gravity. Statistically significant differences were seen in 11 out of 16 organs between BCG-infected mice and the other infected mice. * p < 0.05; ** p < 0.01; *** p < 0.001, and **** p < 0.0001 (Kruskal–Wallis H test).