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. 2020 May 5;142(27):11734–11742. doi: 10.1021/jacs.9b13907

Figure 2.

Figure 2

Efficient BTK degradation in cells. (A) Western blot evaluation of BTK levels in Mino cells in response to various concentrations of RC-2, IR-2, NC-1, and RC-3, after 24 h of incubation. (B) Quantification of BTK levels in (A) by normalization to the β-actin house-keeping gene in Mino cells. DC50 and Dmax were calculated by fitting the data to a second-order polynomial using Prism software. (C) Summary of the DC50 and Dmax values for the PROTACs in Mino cells described in (A) and Supporting Figure 2.