Figure 1.
Nasal organoid growth characteristics. (A–C) Light microscopy of organoid formation over three weeks. (A) Non-CF (B) G551D/Unknown (MF/RF) (C) F508del/F508del (MF/MF). (D) The mean total surface area (TSA) and mean luminal area (LA) at 21 days of culture for non-CF (n = 6), MF/RF (n = 5), and MF/MF (n = 11) subjects’ organoids. MF = Minimal Function; RF = Residual Function. Scale = 250 µm. * p = 0.02, ** p = 0.005, *** p = 0.0001, ns = not significant.
