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. 2020 May 29;11(6):603. doi: 10.3390/genes11060603

Figure 6.

Figure 6

Baseline lumen ratio. Zoomed-in section of a well to show F508del/G551D organoids (A) masking of the organoid’s total surface area and (B) masking of the same organoids’ luminal areas. (C) Baseline lumen to total surface area ratio comparing non-CF (n = 6) to CF patients with residual function (n = 5) and minimal function mutations (n = 11). (D) Pearson correlation comparing the average organoid BLR for each person and the corresponding change in short-circuit current (∆Isc) after forskolin stimulation in the ussing chamber. Not all subjects from (C) had corresponding short-circuit current measurements. Filled circle = Non-CF; Open square = MF/RF; Open circle = MF/MF. Scale = 200 µm. * p = 0.02, *** p = 0.0001, and **** p < 0.0001.