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. 2020 May 29;11(6):603. doi: 10.3390/genes11060603

Figure 7.

Figure 7

FIS assay. (A–C) Three representative brightfield and DAPI-stained images at times 0, 1, and 8 h for non-CF (A), F508del/P67L (B), and F508del/F508del (C) CFTR HNE organoids. (D) Average fractional change from baseline over 8 h for each subject, dotted lines highlighting the 1- and 8-h timepoints. (E) 1-h vs. 8-h time points for the average fractional change of non-CF, F508del/P67L, and F508del/F508del organoids (n = 1). (A) Corresponds with Video S5, (B) corresponds with Video S6, and (C) corresponds with Video S7. ns = not significant; * p = 0.0441, ** p = 0.0023, and **** p < 0.0001.