Figure 4.

Iron mobilization from ferritin and hemosiderin by deferiprone (L1). Cartoon image of iron mobilization by L1, from the oxohydroxy polynuclear iron complex found in ferritin and hemosiderin. Iron binding by L1 begins from the outer surface of the iron core. Iron binding from the inner iron core is much more difficult to achieve due to lower accessibility by L1 and also because the polynuclear iron complex formation is much denser than the outer surface of the iron core.