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. 2020 Jun 10;9(6):1443. doi: 10.3390/cells9061443

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) Hierarchical clustering of samples based on microRNA (miRNA) profiles observed in total plasma EVs from AD patients and CTRLs. The most variant (according to coefficient of variation) miRNAs detected in NDEVs were used for clustering analysis (Pearson correlation, average linkage). Rows are centered and unit variance scaling is applied to normalized expression values. Color indicates relative up- (red) or downregulation for each miRNA (row). (b) Principle component analysis based on the most variant miRNAs in NDEVs.