Figure 4.

Vaccine efficacy of recombinant SmChEs in a mouse model of schistosomiasis. Graphs show parasitology burdens from vaccinated and control mice. (A) Trial 1 adult worms. (B) Trial 2 adult worms. (C) Trial 1 liver eggs per gram (EPG). (D) Trial 2 liver EPG. (E) Trial 2 intestinal EPG. (F) Hatching viability of eggs obtained from the pooled livers of control and vaccinated mice from trial 2. Data are the average of ten replicate counts ± SEM of hatched miracidia. Significance and percent reductions (if any) for all parameters are measured relative to the control group. Significance determined by the student’s t test, where * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001.