Figure 4.

Overview of the cell biological mechanisms that have been implicated in amyloid-protein-induced cellular damage and apoptosis and peripheral neuropathy, both in cells producing an amyloid protein and in other cells affected by amyloid or amyloid protein aggregates. Such “amyloid target cells” include cell types that degrade amyloid and protein aggregates after phagocytosis (macrophages and microglia), as well as Schwann cells (involved in nerve function and integrity) and endothelial cells (involved in microangiopathy).