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The schematic of the neural patterning principle: (A) Development of the neural tube (I-III) and the signaling governs the neural tube (which will develop into midbrain) at the D-V axis (III, bottom) and (B) the principle of neural development guided by the gradient signaling along A-P axis. Wnt regulates the development of the forebrain, midbrain, and hindbrain gradients of RA and Fgf involved in the segmentation of hindbrain and the spinal cord.
