Table 1.
Morphological and biochemical values in different experimental groups.
| Group | CN | CKD | Trp | CKDTrp | p Value | ||
|---|---|---|---|---|---|---|---|
| Factor | CKD | Trp | CKD × Trp | ||||
| Mortality | 0% | 0% | 0% | 0% | |||
| Body weight (BW) (g) | 349 ± 9 | 369 ± 15 | 350 ± 6 | 360 ± 10 | NS | NS | NS |
| Left kidney weight (g) | 1.43 ± 0.04 | 1.64 ± 0.07 * | 1.55 ± 0.03 | 1.67 ± 0.04 * | 0.001 | NS | NS |
| Left kidney weight/100g BW | 0.41 ± 0.01 | 0.45 ± 0.01 * | 0.44 ± 0.01 * | 0.47 ± 0.01 * | 0.004 | 0.01 | NS |
| Systolic BP (mmHg) | 136 ± 1 | 153 ± 1 * | 136 ± 1 # | 140 ± 1 # | <0.001 | <0.001 | <0.001 |
| Diastolic BP (mmHg) | 70 ± 3 | 70 ± 2 | 70 ± 3 | 70 ± 3 | NS | NS | NS |
| MAP (mmHg) | 92 ± 2 | 97 ± 1 * | 92 ± 1 # | 93 ± 2 # | 0.045 | NS | NS |
| Creatinine (μM) | 12 ± 0.3 | 12.7 ± 0.3 | 10 ± 0.2 *,# | 9.9 ± 0.1 *,# | NS | 0.001 | NS |
Data are shown as means ± S.E.M. A two-way ANOVA with a Tukey’s post hoc test was performed for statistical analysis. CKD × Trp = interaction of CKD and Trp. n = 8/group. * p < 0.05 vs. CN. # p < 0.05 vs. CKD. BP = blood pressure. MAP = mean arterial pressure. NS = not significant.