Table 2.
Epigenetic factors involved in the regulation of adipogenesis.
| Regulator | Effect on Adipogenic Differentiation | References | |
|---|---|---|---|
| Chromatin Remodelling Complex | In Vitro | In Vivo | |
| SWI/SNF | Promotes | - | [91] |
| Lysine methyltransferases | |||
| SETDB1 | Inhibits | - | [95,96] |
| G9a | Inhibits | Inhibits | [98] |
| Nsd2 | Promotes | Promotes | [99] |
| MLL3/4 | Promotes | Inhibits | [103] |
| Ezh2 | Promotes | - | [94,102] |
| Ehmt1 | - | Promotes | [104] |
| Lysine demethylases | |||
| LSD1 | Promotes | Promotes | [95,97] |
| Kdm5 | Promotes | - | [100] |
| Arginine methyltransferases | |||
| CARM1 | Promotes | Promotes | [90,105] |
| PRMT5 | Promotes | - | [106,107] |
| Histone acetyltransferases | |||
| Gcn5/PCAF | Promotes | Promotes | [110] |
| CBP/p300 | Promotes | Promotes | [111,112] |
| Epigenetic reader BRD4 | Promotes | Promotes | [114,115] |
| Histone deacetylases | |||
| HDAC 1 | Inhibits | - | [117] |
| HDAC 1 and 2 | Promotes | - | [119] |
| HDAC 9 | Inhibits | [120] | |
| Sirt 1 | Inhibits | Inhibits | [123,124,132] |
| Sirt 2 | Inhibits | - | [125] |
| Sirt 6 | Promotes | Promotes | [126] |
| Sirt 7 | Promotes | Promotes | [121] |
| DNA methyltransferase | |||
| Dnmt1 | Promotes (clonal expansion) | - | [129] |
| DNA demethylases | |||
| Tet 1 and 2 | Promotes | - | [131] |