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Synopsis of the direct pro-neuroinflammatory effects pathological Aβ•CaSR signaling evokes in NAHAs. The administration of a CaSR negative allosteric modulators (NAM) nearly totally switches off (in the case of IL-6) or remarkably mitigates (in the case of MCP-2, s-ICAM-1, and RANTES) the Aβ•CaSR signaling-evoked noxious pro-neuroinflammatory upshots. “↑” denotes upregulation. Abbreviations as in the text.
