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. 2020 Jun 2;8(2):269. doi: 10.3390/vaccines8020269

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of monoclonal antibodies on the H. capsulatum sterol metabolism. (A–D) Abundance profiles of ergosterol biosynthetic enzymes: (A) 3-hydroxy-3-methylglutaryl coenzyme A reductase HMG2, (B) C-4 methylsterol oxidase ERG25, (C) 3-ketosteroid reductase ERG27 and (D) cytochrome P450 sterol C-22 desaturase ERG5. (E) Heatmap of the sterol species. (F,G) Abundance profiles of sterols H. capsulatum cells treated with monoclonal antibodies: (F) cholesterol, (G) ergosterol and (H) β-sitosterol (internal standard). Abbreviations: CTRL, control; UC, untreated control without hybridoma medium. t-test: NS, not significant; * p ≤ 0.05 compared to the control sample.