TABLE 1.

Abundance (%) of sequence variants common to both libraries for each week that bear mutations associated with a reduced accumulation.

Variants		Week 1	Week 2	Week 3	Week 4	Rate of decrease* (times)
Ins:C253	L1	20.1103	0.1045	0.0408	0.7745	26.0
	L2	24.7860	0.1622	0.0733	0.5159	48.0
Ins:G254	L1	5.3295	0.0224	0.0056	0.2507	21.3
	L2	8.1040	0.0468	0.0193	0.1944	41.7
Ins:U254	L1	1.3632	0.0073	0.0039	0.0487	28.0
	L2	1.4970	0.0121	0.0051	0.0333	45.0
Ins:A254	L1	1.3605	0.0091	0.0022	0.0602	27.6
	L2	2.8546	0.0202	0.0064	0.0643	44.4

*Rate of decrease: abundance at week 1/abundance at week 4.