TABLE 2.

Abundance (%) of sequence variants common to both libraries for each week that bear mutations associated with an increased accumulation.

Variants		Week 1	Week 2	Week 3	Week 4	Rate of increase* (times)
Ins:A55	L1	0.5989	0.9771	1.0361	1.1314	1.9
	L2	0.5156	0.7862	0.8788	0.6088	1.2
Del:A55	L1	0.0447	0.5511	0.9814	4.2924	96.0
	L2	0.0438	0.5085	0.8994	4.1564	94.9
Sub:G168A	L1	0.1189	0.3843	0.2864	0.2567	2.2
	L2	0.1148	0.2978	0.2957	0.2603	2.3
Del:U296	L1	0.2128	0.6236	0.6481	0.5994	2.8
	L2	1.9319	6.1942	6.4775	4.9930	2.6
Del:A118	L1	0.1833	0.5856	0.4376	0.3842	2.1
	L2	0.2006	0.5037	0.5246	0.4926	2.5

*Rate of increase: abundance at week 4/abundance at week 1.