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. 2020 May 21;8(2):240. doi: 10.3390/vaccines8020240

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Antibody responses in sera and BALFs elicited by intranasal immunizations with rH7 proteins formulated in PELC nanoemulsion plus CpG. (A) Groups of mice were intranasally immunized with three doses of 5 or 20 µg rH7 protein formulated with PELC/CpG, poly (I:C), or FliC over a 3-week interval. Serum and BALF samples were collected and analyzed using ELISA to measure (B,D) H7-specific IgG and (C,E) IgA antibody titers. Hemagglutination (HA) inhibition and neutralization antibody titers in sera were respectively determined using (F) hemagglutination inhibition (HI) and (G) microneutralization (MN) assays. n.d. (not detected). Statistical analysis consisted of one-way ANOVA. *, p < 0.05; **, p < 0.01.