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Protective immunity against the H7N9 virus induced by intranasal immunization with rH7 proteins. Mice were challenged with 10 LD50 of the H7N9 virus 3 weeks after the final intranasal immunizations. (A) Survival and (B) body weight loss rates were monitored for 14 days. Mice whose body weights fell below 75% of their initial weights were sacrificed.
