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Different immune responses associated with genesis and progression of hepatocellular carcinoma owing to the reduction in antitumour immune response. CD: Cluster of differentiation; CTLA-4: cytotoxic T-lymphocyte-associated protein-4; IFNγ: interferon-gamma; IL: interleukin; LAG-3: lymphocyte-activation gene 3; PD-1: programmed cell death-1; PD-L1: programmed cell death-ligand1; NK: Natural Killer cells; TIM-3: T-cell immunoglobulin mucin-3.
