Figure 3.

Intrinsically disordered region (IDR) definition at the protein level. Example of the majority and zero consensus definitions when more than one structure maps to the same protein sequence. Missing residue regions are in red, structured parts in blue and unknown residues as a gray line. The N-terminus is always disordered with an IDR according to the zero consensus. PDB₁ limits the length of the IDR in the zero consensus because it is the only one which has structured residues in the region between the black lines. Consequently, the IDR of the majority consensus is longer and contains those residues which are missing in at least 3 out of 5 PDB chains (more than 50%). Unknown residues, i.e., those not considered to grow the crystal, are excluded and do not affect the consensus definitions.