Figure 6.

A schematic diagram representing the key differences between Integra, BTM and allogenic native skin grafts in terms of inflammatory and wound healing mediators’ expression levels. Growth factors showing differential expression at protein levels in grafts and cell types known to secrete these growth factors are presented. (a) Allogenic native skin graft (and to a lesser degree BTM graft) triggers significantly higher inflammation response in the host, compared to (b) Integra^®, resulting in greater fibroblast growth and vascularisation. Integra^® grafts, however, are more progressed towards ECM remodelling phase within this time point, possibly triggered by an excessive amount of collagen in the graft. The arrows suggest pathways, based on the literature below, which link the growth factors to the grafting outcomes. Only the feed-forward pathways (and no inhibitory pathways) are presented. Abbreviations: polymorphonuclear cells (PMN), macrophages (Mac), mast cells (MC), basal keratinocytes (KC), endothelial cells (EC), and dendritic cells (DC) [17,19,21,22,23,24,25,26,27,28,29,30,31].