Table 1.
List of some human diseases associated to machineries involved in H3K4me3 and H2Bub.
| Complex. | Pathologies Associated | Reference |
|---|---|---|
| COMPASS/Set1 | Lymphoblastic and acute myeloid leukemia | [130] |
| Kabuki syndrome 1 | [135] | |
| Hematopoiesis | [136] | |
| Embryonic stem cell (ESC), induced pluripotent stem cell (iPSC) and neuronal stem cell proliferation | [130] | |
| Embryogenesis | [130] | |
| PAF1c | Parathyroid carcinoma (PC) | [137] |
| ESC pluripotency maintenance | [138] | |
| Mitochondrial autophagy | [139] | |
| PRDM9 | Defective synapsis and male infertility | [140,141] |
| Rad6 | Male infertility | [97,134] |
| Ovarian cancer | [142] |