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. 2020 May 27;8(2):251. doi: 10.3390/vaccines8020251

Figure 2.

Figure 2

Inhibition of binding of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) RBD-Fc to hDPP4 receptor by sera of immunized mice: C57BL/6 mice were immunized i.m. with MERS-RBD-Fd with or without alum and rASP-1 alone or together using different combinations and/or formulations (Table 1 and X-axis legend). Sera samples were collected on day 7 post-2nd immunization and assayed for inhibition of the binding of MERS-CoV RBD-Fc to Huh-7 cells expressing MERS-CoV receptor DPP4. The data represents the mean and standard error (SEM) of percentage inhibition of binding from at least two independent experiments with 3 to 5 mice per group. “+” indicates the presence and “−“ indicates the absence of the protein or adjuvants in the formulation. Statistics was performed using one-way ANOVA with Tukey’s multiple comparison. p < 0.05: *, p < 0.0001: ****. ND: not detectable.