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PK parameters of Pamiparib.
| Species | T1/2 (h) | AUC 0-inf/Dose (ng.h/mL per mg/kg) |
Clearance (mL/kg/min) |
Vdss (L/kg) |
F (%) |
|---|---|---|---|---|---|
| Mouse | 3.2 ± 0.5 | 552 ± 194 | 29.9 ± 2.4 | 5.7 ± 0.5 | 99 ± 35 |
| Rat | 5.5 ± 0.8 | 694 ± 124 | 22.7 ± 2.8 | 6.9 ± 0.7 | 94 ± 17 |
| Dog | 3.6 ± 1.9 | 800 ± 95 | 15.2 ± 1.0 | 2.1 ± 0.2 | 73 ± 4.0 |
