Table 2.
FLC in CIS/MS and controls.
| A | CIS/MS (n = 526) | Controls (n = 219) | p-value |
|---|---|---|---|
| CSF KFLC (mg/L) | 3.7 (1.0–10.1) | 0.2 (0.1–0.4) | <0.001 |
| Serum KFLC (mg/L) | 12.4 (9.8–15.7) | 13.7 (10.6–16.9) | 0.001 |
| KFLC index | 75.6 (21.8–197.0) | 2.8 (2.2–4.9) | <0.001 |
| KFLC index ⩾ 6.6 | 460 (87.5) | 38 (17.4) | – |
| B | CIS/MS (n = 543) | Controls (n = 202) | p-value |
| CSF LFLC (mg/L) | 0.5 (0.2–1.3) | 0.2 (0.2–0.3) | < 0.001 |
| Serum LFLC (mg/L) | 11.3 (9.2–13.7) | 12.1 (9.8–15.4) | 0.001 |
| LFLC index | 11.6 (5.3–33.3) | 3.3 (2.5–4.7) | < 0.001 |
| LFLC index ⩾ 6.9 | 359 (68.3) | 30 (13.7) | – |
FLC: free light chains; CIS: clinically isolated syndrome; MS: multiple sclerosis; A: KFLC in CIS/MS and controls; CSF: cerebrospinal fluid; KFLC: kappa free light chain; index: FLC quotient/albumin quotient; B: LFLC in CIS/MS and controls; LFLC: lambda free light chains; IQR: interquartile range.
Values are given as n (%) or as median (IQR).