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. 2020 Jul 10;20:640. doi: 10.1186/s12885-020-07106-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Panel a FXR expression in a case of breast cancer with bone metastases (score of 8) and a case with lung metastases (score of 2). The FXR score is higher in bone metastases (8) compared to lung metastases (2). Scale bars = 40 and 50 μm Panel b FXR expression in primary tumors in relation with first metastatic site. FXR was expressed in 98% of primary breast cancer with bone metastasis (median score 6) and in 68% (median score 4.5) with visceral metastasis. In grade 3 cancers, the predictive value of FXR was improved. The bone predictive value was 91% and the visceral one was 43%