Figure 7.

Human IgG subclass responses to recombinant native G and F0. Shown are IgG subclass levels, IgG₁ (a), IgG₂ (b), IgG₃ (c) and IgG₄ (d) in sera from 18 healthy adult individuals to recombinant, native G and F0 (x-axes), (y-axis: optical density values; IgG₁, IgG₂, IgG₃ and IgG₄). Horizontal lines within scatter plots indicate median values. The cut-off (mean of buffer control plus three times standard deviation) is indicated by horizontal red lines. Significant differences between G and F0-specific antibody levels are indicated (*** p < 0.001; **** p < 0.0001).