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. 2020 Jun 13;8(2):303. doi: 10.3390/vaccines8020303

Table 1.

Fungal pattern recognition receptors and their ligands.

Pattern Recognition Receptor Ligand Reference
CLR a Dectin-1 β-(1,3)-glucan [8]
Dectin-2 High mannose [9]
Dectin-2/Dectin-3 α-mannan [10]
Mannose receptor N-linked mannan [11]
Mannose receptor Chitin [12]
Mincle b α-mannan [13]
Galectin-3 β-(1,2)-mannoside [14]
DC-SIGN N-linked mannan [15]
Others NOD-2 c Chitin [12]
TLR d TLR-2 Phospholipomannan [16]
TLR-2 β-(1,6)-glucan [11]
TLR-4 O-linked mannans [11]
TLR-7 ssRNAe [17]
TLR-9 CpG DNA [18]
TLR-9 Chitin [12]

Note: Some of the pattern recognition receptors and ligands that are involved in innate resistance to fungal infections. The biological responses elicited by receptor–ligand binding are discussed in the text. a C-type lectin receptors; b Macrophage inducible Ca2+-dependent lectin receptor; c Nucleotide-binding oligomerization domain-containing protein 2; d Toll-like receptors; e Single stranded RNA.