Table 1.
Pattern Recognition Receptor | Ligand | Reference | |
---|---|---|---|
CLR a | Dectin-1 | β-(1,3)-glucan | [8] |
Dectin-2 | High mannose | [9] | |
Dectin-2/Dectin-3 | α-mannan | [10] | |
Mannose receptor | N-linked mannan | [11] | |
Mannose receptor | Chitin | [12] | |
Mincle b | α-mannan | [13] | |
Galectin-3 | β-(1,2)-mannoside | [14] | |
DC-SIGN | N-linked mannan | [15] | |
Others | NOD-2 c | Chitin | [12] |
TLR d | TLR-2 | Phospholipomannan | [16] |
TLR-2 | β-(1,6)-glucan | [11] | |
TLR-4 | O-linked mannans | [11] | |
TLR-7 | ssRNAe | [17] | |
TLR-9 | CpG DNA | [18] | |
TLR-9 | Chitin | [12] |
Note: Some of the pattern recognition receptors and ligands that are involved in innate resistance to fungal infections. The biological responses elicited by receptor–ligand binding are discussed in the text. a C-type lectin receptors; b Macrophage inducible Ca2+-dependent lectin receptor; c Nucleotide-binding oligomerization domain-containing protein 2; d Toll-like receptors; e Single stranded RNA.