Table 2.
Summary of innate immune receptors in fungal infections.
| Organism | Innate Resistance | Acquired Response |
|---|---|---|
| Blastomyces spp. | CR3, CARD9-dependent | CARD9-dependent Dectin-2, Dectin-3, MR |
| Coccidioides spp. | Dectin-1 MyD88-dependent IL-1R |
CARD9-dependent Dectin-2 |
| Cryptococcus spp. | CARD9-dependent Dectin-3, FcRγ MyD88-dependent TLR-2, IL-18R |
? |
| Histoplasma spp. | MyD88-dependent TLR-7/9 a,b | CARD9-dependent Dectin-2 |
| Paracoccidioides spp. | Resistance - Dectin-1 MyD88-probably TLR-2 Galectin |
? |
Conclusions about the receptors involved in innate resistance to infection and the immune response to infection. They are based on in vivo data reviewed in this paper. However, the effects of many receptors on innate resistance and acquired immunity have not been tested. a Receptors involved in phagocytosis are CR3 and Dectin-1; b receptors involved in cytokine production are Dectin-1, Dectin-2, TLR-2, and CR3. CR3; complement receptor 3; CARD9: caspase recruitment domain family, member 9; MyD88: Myeloid differentiation primary response 88; FcRγ: Fcγ receptor; TLR-2: toll like receptor 2; IL-18R: IL-18 receptor.