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. 2020 Jun 25;21(12):4516. doi: 10.3390/ijms21124516

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Analysis of cytokine expression and secreted factors in AD neuronal cultures upon Aβ-S8C stimulation. (A) Heatmap of Pearson correlation analysis of microarrays data from AD neural differentiation under Aβ-S8C stimulation (AD2-4_ Aβ1 and AD2-4_ Aβ2) or control (AD2-4_ CTR1 and AD2-4_ CTR2) showing the differential expression of cytokines. The highlighted genes in green represent a cluster of cytokines downregulated upon Aβ-S8C stimulation whereas the highlighted genes in red represent an upregulated cluster of cytokines. (B) Human cytokine array showing the effect of the Aβ-S8C peptide on the secreted factors of neuronal cultures from pooled AD2-2 and AD2-4 culture supernatants of control condition and 72 h of Aβ-S8C stimulation. (C) Quantitative analysis of the secreted factors shows that Aβ-S8C treatment decreases the amount of secreted cytokines in AD neuronal cultures.