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. 2020 Jun 25;21(12):4516. doi: 10.3390/ijms21124516

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Aβ-S8C stimulated AD neuronal cultures activate a protein-protein interaction network, which includes APP and HSPA5. (A) Venn diagram dissecting 95 genes expressed in Aβ-S8C stimulated AD neuronal cultures from genes expressed in AD control and healthy neuronal cultures with and without Aβ-S8C stimulation. (B) Dot plot of gene ontologies (biological process) overrepresented in the 95 AD_Aβ genes. (C) Dot plot of KEGG pathways overrepresented in the 95 AD_Aβ genes. (D) Protein–protein interaction network derived from the 95 AD_Aβ genes with APP and HSPA5. Nodes from the 95 genes are colored green and the nodes added using the Biogrid database to connect the network are colored red.