Table 5.

QTc Abnormalities and Medical Outcomes

Patient No.	QTc Baseline	QTc Peak	Concurrent QTc-Prolonging Drugs	Medical Response	Finished Course of Bedaquiline?
1	384	469	CFZ	None	Yes
3	439	507	CFZ, LFX	Bedaquiline discontinued	No
4	411	475	CFZ, LFX	None	Yes
11	442	536	MFX	None because QTc was 432 the day after the peak value	Yes
12	400	610	LFX	K+ = 2.2; bedaquiline stopped and restarted two weeks after K+ replenished	Yes
14	483 (3 months after bedaquiline started)	546 (1 day after bedaquiline was stopped)	MFX, CFZ, Effexor, Zofran	MFX and CFZ stopped sequentially until QTc decreased	Yes

Abbreviations: CFZ, clofazimine; LFX, levofloxacin; K+, potassium; MFX, moxifloxacin; QTc, corrected QT interval.